Bringing AI-driven protein-design tools to biologists everywhere
Founded by Tristan Bepler PhD ’20 and former MIT professor Tim Lu PhD ’07, OpenProtein.AI offers researchers open-source models and other tools for protein engineering.
Proteins
MIT engineers design proteins by their motion, not just their shape
An AI model generates novel proteins based on how they vibrate and move, opening new possibilities for dynamic biomaterials and adaptive therapeutics.
MIT scientists debut a generative AI model that could create molecules addressing hard-to-treat diseases
BoltzGen generates protein binders for any biological target from scratch, expanding AI’s reach from understanding biology toward engineering it.
3 Questions: On biology and medicine’s “data revolution”
Professor Caroline Uhler discusses her work at the Schmidt Center, thorny problems in math, and the ongoing quest to understand some of the most complex interactions in biology.
Researchers glimpse the inner workings of protein language models
A new approach can reveal the features AI models use to predict proteins that might make good drug or vaccine targets.
With AI, researchers predict the location of virtually any protein within a human cell
Trained with a joint understanding of protein and cell behavior, the model could help with diagnosing disease and developing new drugs.
An ancient RNA-guided system could simplify delivery of gene editing therapies
The programmable proteins are compact, modular, and can be directed to modify DNA in human cells.
AI system predicts protein fragments that can bind to or inhibit a target
FragFold, developed by MIT Biology researchers, is a computational method with potential for impact on biological research and therapeutic applications.
AI model deciphers the code in proteins that tells them where to go
Whitehead Institute and CSAIL researchers created a machine-learning model to predict and generate protein localization, with implications for understanding and remedying disease.
A new computational technique could make it easier to engineer useful proteins
MIT researchers plan to search for proteins that could be used to measure electrical activity in the brain.