Genetic engineering
Genetic engineering

Genetic engineering

Artificial Intelligence Brain and cognitive sciences Broad Institute CRISPR DNA Genetic engineering Howard Hughes Medical Institute (HHMI) McGovern Institute Neuroscience Research RNA School of Engineering

Rationale engineering generates a compact new tool for gene therapy

Researchers redesign a compact RNA-guided enzyme from bacteria, making it an efficient editor of human DNA.

Artificial Intelligence Brain and cognitive sciences Broad Institute CRISPR DNA Genetic engineering Genetics Howard Hughes Medical Institute (HHMI) McGovern Institute Proteins Research RNA School of Science

An ancient RNA-guided system could simplify delivery of gene editing therapies

The programmable proteins are compact, modular, and can be directed to modify DNA in human cells.

Algorithms Artificial Intelligence Biological engineering Broad Institute Cells Computer science and technology Data Electrical engineering and computer science (EECS) Genetic engineering Genetics IDSS Laboratory for Information and Decision Systems (LIDS) machine learning MIT Schwarzman College of Computing MIT-IBM Watson AI Lab Research School of Engineering

A causal theory for studying the cause-and-effect relationships of genes

By sidestepping the need for costly interventions, a new method could potentially reveal gene regulatory programs, paving the way for targeted treatments.

Algorithms Artificial Intelligence Bacteria Biological engineering Biology Brain and cognitive sciences Broad Institute Computational biology Computer science and technology CRISPR Data DNA Genetic engineering Genome Genome editing McGovern Institute Microbes National Institutes of Health (NIH) Research RNA School of Engineering School of Science

Search algorithm reveals nearly 200 new kinds of CRISPR systems

By analyzing bacterial data, researchers have discovered thousands of rare new CRISPR systems that have a range of functions and could enable gene editing, diagnostics, and more.

Agriculture Artificial Intelligence Bioengineering and biotechnology Biological engineering Biology Carbon dioxide chemistry Climate change Collaboration Food Funding Genetic engineering Grants Greenhouse gases J-WAFS machine learning Plants Research School of Engineering School of Science Synthetic biology Water Whitehead Institute

Inaugural J-WAFS Grand Challenge aims to develop enhanced crop variants and move them from lab to land

Matt Shoulders will lead an interdisciplinary team to improve RuBisCO — the photosynthesis enzyme thought to be the holy grail for improving agricultural yield.