RNA
RNA

RNA

Artificial Intelligence Brain and cognitive sciences Broad Institute CRISPR DNA Genetic engineering Howard Hughes Medical Institute (HHMI) McGovern Institute Neuroscience Research RNA School of Engineering

Rationale engineering generates a compact new tool for gene therapy

Researchers redesign a compact RNA-guided enzyme from bacteria, making it an efficient editor of human DNA.

Alumni/ae Artificial Intelligence Bioengineering and biotechnology Biology Brain and cognitive sciences Chemical engineering Computer Science and Artificial Intelligence Laboratory (CSAIL) Computer science and technology Data DNA EAPS Mechanical engineering NASA Profile RNA School of Engineering School of Science Staff Whitehead Institute

At the core of problem-solving

Stuart Levine ’97, director of MIT’s BioMicro Center, keeps departmental researchers at the forefront of systems biology.

Artificial Intelligence Brain and cognitive sciences Broad Institute CRISPR DNA Genetic engineering Genetics Howard Hughes Medical Institute (HHMI) McGovern Institute Proteins Research RNA School of Science

An ancient RNA-guided system could simplify delivery of gene editing therapies

The programmable proteins are compact, modular, and can be directed to modify DNA in human cells.

Algorithms Artificial Intelligence Bacteria Biological engineering Biology Brain and cognitive sciences Broad Institute Computational biology Computer science and technology CRISPR Data DNA Genetic engineering Genome Genome editing McGovern Institute Microbes National Institutes of Health (NIH) Research RNA School of Engineering School of Science

Search algorithm reveals nearly 200 new kinds of CRISPR systems

By analyzing bacterial data, researchers have discovered thousands of rare new CRISPR systems that have a range of functions and could enable gene editing, diagnostics, and more.