CRISPR
CRISPR

CRISPR

Artificial Intelligence Brain and cognitive sciences Broad Institute CRISPR DNA Genetic engineering Howard Hughes Medical Institute (HHMI) McGovern Institute Neuroscience Research RNA School of Engineering

Rationale engineering generates a compact new tool for gene therapy

Researchers redesign a compact RNA-guided enzyme from bacteria, making it an efficient editor of human DNA.

Artificial Intelligence Biological engineering Brain and cognitive sciences CRISPR Electrical engineering and computer science (EECS) Health sciences and technology History of MIT History of science McGovern Institute MIT Schwarzman College of Computing Neuroscience Picower Institute School of Engineering School of Science

MIT’s McGovern Institute is shaping brain science and improving human lives on a global scale

A quarter century after its founding, the McGovern Institute reflects on its discoveries in the areas of neuroscience, neurotechnology, artificial intelligence, brain-body connections, and therapeutics.

Artificial Intelligence Brain and cognitive sciences Broad Institute CRISPR DNA Genetic engineering Genetics Howard Hughes Medical Institute (HHMI) McGovern Institute Proteins Research RNA School of Science

An ancient RNA-guided system could simplify delivery of gene editing therapies

The programmable proteins are compact, modular, and can be directed to modify DNA in human cells.

Algorithms Artificial Intelligence Bacteria Biological engineering Biology Brain and cognitive sciences Broad Institute Computational biology Computer science and technology CRISPR Data DNA Genetic engineering Genome Genome editing McGovern Institute Microbes National Institutes of Health (NIH) Research RNA School of Engineering School of Science

Search algorithm reveals nearly 200 new kinds of CRISPR systems

By analyzing bacterial data, researchers have discovered thousands of rare new CRISPR systems that have a range of functions and could enable gene editing, diagnostics, and more.